Morning dose: allow enough time
Wake up early enough to sip your morning prep slowly without rushing or making yourself nauseated, and finish the dose and all required liquids at least four hours before your procedure. Follow any earlier facility cutoff.
For the three-dose MiraLAX 32/32/32 regimen ONLY: if your bowel movements are completely clear on the procedure morning, Dr. Dainiak allows a minimum of 16 ounces of the correctly mixed morning MiraLAX solution instead of the full 32 ounces. Do not drink less than 16 ounces or skip the morning dose. If output is not completely clear, complete the prescribed 32 ounces. Do not use yesterday’s clear output alone to decide to reduce today’s dose. Keep the first two 32-ounce doses unchanged.
Mix the morning solution exactly as directed: the entire second 8.3-ounce bottle in 64 ounces of clear liquid. This exception changes only how much of that prepared solution you drink, not its concentration. Do not take dry powder or concentrate it into 16 ounces. This exception does not apply to any other prep regimen or remove required hydration.
Even when output looks clear, bile and mucus can accumulate in the colon overnight and obscure polyps. The morning prep helps wash them away. This is for your safety. If you cannot tolerate the required amount or finish before the cutoff, contact the procedure team; do not drink after the cutoff or substitute a few sips.
If the volume makes you feel sick
You do not need to gulp the prep or drink it all at once. Drinking too quickly can stretch your stomach and make you feel nauseated or vomit. Slowing down can make it easier to tolerate, although it cannot guarantee that nausea or vomiting will not occur. The prescribed liquid is important for cleaning the colon and preventing dehydration. This is for your safety.
For Bedford’s prescribed three-dose MiraLAX 32/32/32 prep, you have two days of clear liquids before the procedure. Sip each of the first two 32-ounce portions slowly over its assigned day rather than forcing it down in an hour. If mild nausea develops, slow down and take a break; a break of up to a couple of hours can help during those earlier prep days if you can still finish that day’s portion. Resume slowly as the nausea settles. Keep all three doses on their assigned days, including the essential morning dose.
Between sips, you can vary your permitted clear liquids with clear broth, non-red/purple Jell-O, or dairy-free sorbet without pulp or pieces that melts clear. These are separate clear-liquid choices, not ingredients to add to the prep mixture and not replacements for the prescribed prep volume or any required plain water.
The morning dose and all required liquids must be completed at least four hours before your procedure, or earlier if your facility directs. Do not take a long break that pushes intake past that cutoff. If you cannot finish in time, contact the procedure team rather than rushing, skipping liquid, or drinking after the cutoff.
Other preparations have their own dosing, spacing and water requirements; do not stretch those doses across the day without instructions from the practice. If a shorter preparation has been difficult to tolerate, ask the practice whether the extended three-dose MiraLAX preparation would help. Do not change regimens yourself.
Repeated vomiting, inability to keep fluids down, severe or increasing abdominal pain or swelling, fainting, or markedly reduced urination require prompt medical contact; seek urgent care for severe symptoms. Do not try to push through these symptoms by continuing to drink.
Five days before clear liquids begin
For the five days before you start clear liquids, avoid seeds, nuts, vegetables, granola, trail mix, corn, flaxseed, whole grains and other high-residue foods. These foods can leave material in the colon that is difficult to clean out. Temporarily changing your diet makes the bowel preparation easier and helps the doctor see the colon lining clearly. This is for your safety.
During this low-residue period, you can eat chicken, fish, eggs, meat, potatoes without the skin, white rice instead of brown rice, and white bread instead of whole-grain bread. Examples: eggs and white toast for breakfast; chicken and white rice for lunch; steak and mashed potatoes without skins for dinner.
If you are having trouble having a bowel movement during this low-residue period, one capful of MiraLAX in eight ounces of water daily may help. Talk to your doctor first to make sure this is right for you. This is optional constipation guidance before the clear-liquid phase, not an extra dose to add to your prescribed bowel prep.
When you switch to clear liquids, stop solid foods and follow your assigned clear-liquid and bowel-prep instructions. Do not carry this optional daily MiraLAX dose into the prep phase unless your doctor specifically directs you to do so.
A simple guide to your prescribed preparation
Taking SUPREP, step by step
Two doses. The same three steps each time: mix, drink, then drink more water.
It is essential to drink all of the liquid. Not doing so could result in dehydration and kidney problems. This is for your safety.
First, confirm your schedule
Take dose 1 the evening before your colonoscopy. Take dose 2 the next morning, 10–12 hours after dose 1.
Complete the entire morning prep dose and all required water at least four hours before your procedure. Then nothing by mouth, including water, until your care team says you may. This is Bedford’s practice instruction. Follow any earlier fasting cutoff given by your facility.
Your facility may give instructions based on arrival time, which is different from procedure time. If your assigned times conflict with this schedule, call (603) 367-3064 before starting. Do not shorten the interval or skip the water.
Dose 1 · The evening before
Mix → Drink → Drink water
1. Mix
Pour the entire first 6-ounce bottle into the supplied container. Add cool drinking water up to the 16-ounce line. Stir.
The total mixture is 16 ounces. Do not add 16 ounces of water to the bottle.
2. Drink
Drink all 16 ounces of the mixed solution.
3. Drink two more
Fill the container to the 16-ounce line with plain water and drink it. Repeat once.
Drink both containers of water over the next hour.
It is essential to drink all of the liquid. Not doing so could result in dehydration and kidney problems. This is for your safety.
Dose 2 · The morning of your colonoscopy
Mix → Drink → Drink water
1. Mix
Pour the entire second 6-ounce bottle into the supplied container. Add cool drinking water up to the 16-ounce line. Stir.
The total mixture is 16 ounces. Do not add 16 ounces of water to the bottle.
2. Drink
Drink all 16 ounces of the mixed solution.
3. Drink two more
Fill the container to the 16-ounce line with plain water and drink it. Repeat once.
Drink both containers of water over the next hour.
It is essential to drink all of the liquid. Not doing so could result in dehydration and kidney problems. This is for your safety.
Across both adult doses: 96 ounces (3 quarts) of mixed prep and required water. The extra water is part of the preparation.
What can I eat and drink?
The day before: clear liquids only for the entire day, including breakfast. This is Bedford Gastroenterology’s preparation instruction.
Procedure morning: clear liquids only until four hours before your procedure, then nothing by mouth. Follow any earlier facility cutoff.
Examples: water, pulp-free juice, lemonade, plain tea or black coffee, clear chicken broth, and gelatin without fruit. Avoid red or purple coloring.
No solid food, milk, or alcohol during the clear-liquid phase.
Medicines: check before you start
- Do not take other laxatives with SUPREP.
- Do not take medicines by mouth within 1 hour of starting either dose.
- Tetracycline or fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine need special spacing: at least 2 hours before, or at least 6 hours after, each SUPREP dose. Ask your pharmacist or care team to plan the timing.
- If you have been told you have dehydration or abnormal blood salts (electrolytes), contact your clinician before starting; these need correction first.
Pediatric instructions — ages 12 and older, only with the prescribed pediatric kit
Use two 4.5-ounce bottles, not the adult bottles. Do not use this guide for children under 12.
Take the first dose the evening before and the second the next morning, 10–12 hours later. For each dose:
- Pour one entire 4.5-ounce bottle into the supplied container.
- Add cool water to the 12-ounce line, mix, and drink it all.
- Drink two more containers of plain water, each filled to the 12-ounce line, over the next hour.
That is 36 ounces per dose, or 72 ounces (2.25 quarts) for both doses. Use the prescribing team’s pediatric schedule and liquid-stop time; do not apply an adult schedule without that team’s instructions. The food and medication instructions above also apply. Confirm the child's schedule with the prescribing team.
Bedford practice instructions updated October 26, 2026, using the manufacturer’s mixing, water and medication requirements. Read the medication guide included with your kit for full safety information.
